Cloning and initial characterization of human and mouse Spot 14 genes
Identifieur interne : 003197 ( Main/Exploration ); précédent : 003196; suivant : 003198Cloning and initial characterization of human and mouse Spot 14 genes
Auteurs : Joël-Paul Grillasca [France] ; Marguerite Gastaldi [France] ; Hacène Khiri [France] ; Alexandra Dace [France] ; Nicole Peyrol [France] ; Pascal Reynier [France] ; Janine Torresani [France] ; Richard Planells [France]Source :
- FEBS Letters [ 0014-5793 ] ; 1996.
Abstract
The intricate regulation of Spot 14 expression in rat lipogenic tissues has provided a useful tool in studying nutritional and hormonal factors involved in transcription. To gain insight into its function and its possible involvement in human lipid disorders, we cloned human and mouse Spot 14 genes that shared with the rat gene a strong homology concerning the deduced amino acid sequence (81 and 94%, respectively) as well as the promoter region. The mouse promoter was characterized by transfection studies, while quantitative RT-PCR and in situ hybridization experiments showed that Spot 14 is expressed in human liver and, at a high level, in multiple symmetric lipomatosis nodules.
Url:
DOI: 10.1016/S0014-5793(96)01433-0
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000871
- to stream Istex, to step Curation: 000704
- to stream Istex, to step Checkpoint: 002967
- to stream Main, to step Merge: 003283
- to stream Main, to step Curation: 003197
Le document en format XML
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<front><div type="abstract" xml:lang="en">The intricate regulation of Spot 14 expression in rat lipogenic tissues has provided a useful tool in studying nutritional and hormonal factors involved in transcription. To gain insight into its function and its possible involvement in human lipid disorders, we cloned human and mouse Spot 14 genes that shared with the rat gene a strong homology concerning the deduced amino acid sequence (81 and 94%, respectively) as well as the promoter region. The mouse promoter was characterized by transfection studies, while quantitative RT-PCR and in situ hybridization experiments showed that Spot 14 is expressed in human liver and, at a high level, in multiple symmetric lipomatosis nodules.</div>
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